The church was one of the "Commissioner's" or "Waterloo" churches built in areas of London with a rapidly rising population. The new parish was formed from part of the ancient parish of St Marylebone, and was sometimes called St Marylebone, St Mary.
The church was built in the Greek Revival style of architecture, ornamented by a semi-circular stone portico of six Ionic columns on the south facade, surmounted by a pepperpot tower. In 1874/75 the interior was redesigned by Sir Arthur Blomfield.
The church was again refurbished and reordered in 2000-02.
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